Software and Performance Testing Tools

Software Testing may be a method, that involves, death penalty of a software system program/application and finding all errors or bugs therein program/application in order that the result is going to be a defect-free software system. Quality of any software sys-tem will solely be acknowledged through means that of testing (software testing). Through the advancement of technology round the world, there inflated the quantity of verification techniques and strategies to check the software system before it goes to production and astray to promote. Automation Testing has created its impact within the testing method. Now-a-days, most of the software system testing is finished with the automation tools that not solely lessens the quantity of individuals operating around that software system however additionally the errors which will be loose through the eyes of the tester. Automation take look acting contains test cases that make the work simple to capture totally different eventualities and store them. Therefore, software sys-tem automation testing method plays a significant role within the software system test-ing success. This study aims in knowing differing kinds of software system testing, soft-ware system testing techniques and tools and to match manual testing versus automa-tion testing

The Fallacy of Happiness: A Psychological Investigation of Suicide among Successful People

There are three feelings that prompt a person to take their life: hopelessness, helplessness and worthlessness. Studies have found that the risk of suicide increases with decreasing happiness. In the recent past, people have been left clueless when celebrities and successful people ended their lives despite appearing overtly happy. What prompted them to do so? Modern society today highlights the importance of success over failure. Although we are motivated to be successful in life, it should not become our main gauge of happiness. In the same way we should not let success be our main goal in life and get discouraged by failure. Happiness has been viewed in two ways: as concerning the well-being of a person, and as the opposite of depression. Each one of us has different ways of measuring happiness. The quality of one’s happiness depends on one’s priorities in life. Happiness is not merely something that can be quantified with how much success and failure one has because such metric is very much subjective. How do we prevent a young life from extinguishing? How do we identify suicidal behavior among successful people and help those around? The present chapter covers the possible reasons why successful people commit suicide. Role of media in preventing suicide and measures for preventing suicide by successful people has been discussed

Happiness at Work: A Psychological Perspective

Modern human beings spend their maximum amount of time in the work setting. Hence, how they feel at the workplace has a direct influence on their overall quality of life. Therefore, understanding what makes us happy or unhappy at work is very crucial. Surprisingly, there is an absence of a sound theoretical and conceptual framework for understanding the concept of happiness from the organizational perspective. For developing a conceptual framework for happiness at work, two components are relevant -the external work environment and the internal mental mapping. The concept of happiness in psychology has been equated with pleasure, a mixture of pleasure, engagement and meaning, or with the concept of well-being. A precise definition of happiness is missing. There have been numerous studies on the contributions of positive psychology to happiness and its influence on employees’ well-being and productivity. Most researches concentrate on the external happiness of individuals. But in the future, organizations need to focus on the intrinsic happiness of employees as well, to get the best outcome at the workplace. This chapter covers the causes and consequences of happiness in the workplace. Ways of inculcating happiness at the workplace to increase organizational productivity and create happy employees have also been discussed

The Role of Toll-Like Receptor 4 in the Progression of Keloids

Keloids are highly prevalent in the population and their pathogenesis is largely unknown. T-cell lymphoma research shows that toll like receptor-4 (TLR-4) is highly expressed on CD206+ immunosuppressive macrophages and is implicated in maintaining the tumor microenvironment. Additionally, fibronectin, specifically extra domain A (EDA), is highly expressed and is associated with immunosuppression via the TLR-4 pathway. Assuming that keloids mimic the tumor microenvironment, we hypothesize that TLR-4 is implicated in the pathogenesis of keloids. Using keloid tissue samples and normal breast tissue as a control, immunohistochemistry was performed to observe the presence and co-localization of these markers. Three antibodies were used to examine co-localization of CD-206 with TLR-4 and CD-206 with EDA to determine if these three components were localized to the same region in the keloid tissue. The secondary antibodies were immunofluorescent, and the tissue was analyzed using electron microscopy. Upon analysis, it was found that in keloid tissue CD-206 and TLR-4 were co-localized. To further support the hypothesis, it was found that CD-206 and EDA were also co-localized. In the control group, there was no evidence of co-localization of CD-206 with TLR-4 or with EDA. These findings support the overall hypothesis that TLR-4 is involved in the pathogenesis of keloids. Discovering that CD-206 co-localizes with both TLR-4 and EDA indicates that these three molecules interact to help form the tumor microenvironment needed to support keloid formation. Knowing this information, studies can begin to look into possible immunological targets for keloid treatment that access this immunosuppressive pathway

Restricted rotation about Nsp2-Csp3 bond through π-electronic interactions: A 1H NMR study

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Sustained proliferation in cancer: mechanisms and novel therapeutic targets

Proliferation is an important part of cancer development and progression. This is manifest by altered expression and/or activity of cell cycle related proteins. Constitutive activation of many signal transduction pathways also stimulates cell growth. Early steps in tumor development are associated with a fibrogenic response and the development of a hypoxic environment which favors the survival and proliferation of cancer stem cells. Part of the survival strategy of cancer stem cells may manifested by alterations in cell metabolism. Once tumors appear, growth and metastasis may be supported by overproduction of appropriate hormones (in hormonally dependent cancers), by promoting angiogenesis, by undergoing epithelial to mesenchymal transition, by triggering autophagy, and by taking cues from surrounding stromal cells. A number of natural compounds (e.g., curcumin, resveratrol, indole-3-carbinol, brassinin, sulforaphane, epigallocatechin-3-gallate, genistein, ellagitannins, lycopene and quercetin) have been found to inhibit one or more pathways that contribute to proliferation (e.g., hypoxia inducible factor 1, nuclear factor kappa B, phosphoinositide 3 kinase/Akt, insulin-like growth factor receptor 1, Wnt, cell cycle associated proteins, as well as androgen and estrogen receptor signaling). These data, in combination with bioinformatics analyses, will be very important for identifying signaling pathways and molecular targets that may provide early diagnostic markers and/or critical targets for the development of new drugs or drug combinations that block tumor formation and progression

Parkinson’s disease mouse models in translational research

Animal models with high predictive power are a prerequisite for translational research. The closer the similarity of a model to Parkinson’s disease (PD), the higher is the predictive value for clinical trials. An ideal PD model should present behavioral signs and pathology that resemble the human disease. The increasing understanding of PD stratification and etiology, however, complicates the choice of adequate animal models for preclinical studies. An ultimate mouse model, relevant to address all PD-related questions, is yet to be developed. However, many of the existing models are useful in answering specific questions. An appropriate model should be chosen after considering both the context of the research and the model properties. This review addresses the validity, strengths, and limitations of current PD mouse models for translational research

Modulation in Direct Radiative Forcing Caused by Wind Generated Sea-Salt Aerosols

Sea-salt aerosols, prominent natural aerosols over the ocean, play a vital role in direct and indirect radiative forcing. Since surface winds are the prime cause of sea-salt generation, we have developed an empirical relationship between aerosol optical depth (AOD) and sea-surface winds over the study region (60-70 degrees E; 40 degrees S-20 degrees N). The latitudinal variation of background aerosol optical depth (tau(0)) and the wind index (b) are estimated as they are essential inputs for the estimation of the spatial variation of sea-salt aerosols and are used over the Arabian Sea (AS) to generate spatial heterogeneity of sea-salt aerosols. The latitudinal variation of tau(0) and b show a nearly exponential and linear increase, respectively, as we moved towards the north. We used an empirical-cum-model approach to construct an aerosol system to reproduce the observed AOD and aerosol optical properties. Utilizing this information as input to a radiative transfer model, we worked out direct radiative forcing (DRF) over the study region in the short wave (0.2-4 mu m) and long wave (8-14 mu m) region at the surface, top of the atmosphere (TOA) and in the atmosphere. Short wave cooling at the surface, TOA and heating in the atmosphere are estimated as 40 W m(-2), 32 W m(-2) and 8 W m(-2), respectively. Long wave heating due to the sea-salt aerosols estimated at the surface, TOA and in the atmosphere is about 9 W m-2, 6 W m-2 and 15 W m-2 respectively. Long wave forcing (LWF) partly counterbalances the effect of short wave forcing (SWF) and the cooling at the surface and at TOA. The highest value of such an offset at the surface was observed over the AS (similar to 23%) and that at TOA was similar to 19%, obviously at high wind conditions. This implies that over the AS sea-salt aerosols (in coarse mode) contribute significantly to LWF compared to other adjacent oceanic regions

Spectrophotometric Studies on Electron- Donor-Acceptor Complexes of Aromatic Hydrocarbons with Tetrabromophthalic Anhydride

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